| Aug 7th 2021 | 20:00 | Sheffield United | v. | Birmingham City | ⚽ |
| Aug 10th 2021 | 19:45 | Sheffield United | v. | Carlisle United | ⚽ |
| Aug 14th 2021 | 20:00 | Swansea City | v. | Sheffield United | ⚽ |
| Aug 18th 2021 | 20:00 | West Bromwich Albion | v. | Sheffield United | ⚽ |
| Aug 21st 2021 | 15:00 | Sheffield United | v. | Huddersfield Town | ⚽ |
| Aug 28th 2021 | 15:00 | Luton Town | v. | Sheffield United | ⚽ |
| Sept 11th 2021 | 15:00 | Sheffield United | v. | Peterborough United | ⚽ |
| Sept 14th 2021 | 19:45 | Sheffield United | v. | Preston North End | ⚽ |
| Sept 18th 2021 | 15:00 | Hull City | v. | Sheffield United | ⚽ |
| Sept 25th 2021 | 15:00 | Sheffield United | v. | Derby County | ⚽ |
| Sept 28th 2021 | 15:00 | Middlesbrough | v. | Sheffield United | ⚽ |
| Oct 2nd 2021 | 15:00 | Bournemouth | v. | Sheffield United | ⚽ |
| Oct 16th 2021 | 15:00 | Sheffield United | v. | Stoke City | ⚽ |
| Oct 19th 2021 | 19:45 | Sheffield United | v. | Millwall | ⚽ |
| Oct 23rd 2021 | 15:00 | Barnsley | v. | Sheffield United | ⚽ |
| Oct 30th 2021 | 15:00 | Sheffield United | v. | Blackpool | ⚽ |
| Nov 2nd 2021 | 19:45 | Nottingham Forest | v. | Sheffield United | ⚽ |
| Nov 6th 2021 | 15:00 | Blackburn Rovers | v. | Sheffield United | ⚽ |
| Nov 20th 2021 | 15:00 | Sheffield United | v. | Coventry City | ⚽ |
| Nov 23rd 2021 | 20:00 | Reading | v. | Sheffield United | ⚽ |
| Nov 27th 2021 | 15:00 | Sheffield United | v. | Bristol City | ⚽ |
| Dec 4th 2021 | 15:00 | Cardiff City | v. | Sheffield United | ⚽ |
| Dec 11th 2021 | 15:00 | Sheffield United | v. | Queens Park Rangers | ⚽ |
| Dec 18th 2021 | 15:00 | Fulham | v. | Sheffield United | ⚽ |
| Dec 26th 2021 | 15:00 | Preston North End | v. | Sheffield United | ⚽ |
| Dec 29th 2021 | 19:45 | Sheffield United | v. | Hull City | ⚽ |
| Jan 1st 2022 | 15:00 | Sheffield United | v. | Middlesbrough | ⚽ |
| Jan 15th 2022 | 15:00 | Derby County | v. | Sheffield United | ⚽ |
| Jan 22nd 2022 | 15:00 | Sheffield United | v. | Luton Town | ⚽ |
| Jan 29th 2022 | 15:00 | Peterborough United | v. | Sheffield United | ⚽ |
| Feb 5th 2022 | 15:00 | Birmingham City | v. | Sheffield United | ⚽ |
| Feb 9th 2022 | 15:00 | Sheffield United | v. | West Bromwich Albion | ⚽ |
| Feb 12th 2022 | 15:00 | Huddersfield Town | v. | Sheffield United | ⚽ |
| Feb 19th 2022 | 15:00 | Swansea City | v. | Sheffield United | ⚽ |
| Feb 23rd 2022 | 19:45 | Sheffield United | v. | Blackburn Rovers | ⚽ |
| Feb 26th 2022 | 15:00 | Millwall | v. | Sheffield United | ⚽ |
| Mar 5th 2022 | 15:00 | Sheffield United | v. | Nottingham Forest | ⚽ |
| Mar 12th 2022 | 15:00 | Coventry City | v. | Sheffield United | ⚽ |
| Mar 16th 2022 | 19:45 | Blackpool | v. | Sheffield United | ⚽ |
| Mar 19th 2022 | 15:00 | Sheffield United | v. | Barnsley | ⚽ |
| Apr 2nd 2022 | 15:00 | Stoke City | v. | Sheffield United | ⚽ |
| Apr 9th 2022 | 15:00 | Sheffield United | v. | Bournemouth | ⚽ |
| Apr 15th 2022 | 15:00 | Sheffield United | v. | Reading | ⚽ |
| Apr 18th 2022 | 15:00 | Bristol City | v. | Sheffield United | ⚽ |
| Apr 23rd 2022 | 15:00 | Sheffield United | v. | Cardiff City | ⚽ |
| Apr 30th 2022 | 15:00 | Queens Park Rangers | v. | Sheffield United | ⚽ |
| May 7th 2022 | 15:00 | Sheffield United | v. | Fulham | ⚽ |